Small cell neuroendocrine carcinoma of the uterine cervix: clinicopathological analysis and outcome of 26 cases

To reveal the clinicopathological data and prognostic outcome of 26 cases of small cell neuroendocrine carcinoma of the uterine cervix (SNCUC). In 2004-2014, the cases were retrospective reviewed and clinicopathological data were collected. Survivals were analyzed with Kaplan-Meier methods by SPSS 19.0. The median age of the patients was 42 years. Twenty-one cases (80.8%) were diagnosed as being early stage carcinoma (International Federation of Gynecology and Obstetrics stage I-IIa). Eight cases (30.8%) underwent neoadjuvant chemotherapy (NACT) before surgery. All patients received radical surgery that was followed by adjuvant therapy. The median overall survival period (OS) of all cases was 19.3 months and the median disease-free survival (DFS) time was 16.6 months. SNCUC is rare in female genital tract cancer. Lymph node metastasis and lymphovascular space invasion (LVSI) might occur in the early stage. Cases without parametrial involvement (PM) have better survivals periods than those with PM. Multimodality therapeutic methods could promote a patient outcome of suffering from SNCUC of the uterine cervix.